AiSMART Lab 國立陽明交通大學 電機工程研究所Institute of Electrical and Computer Engineering, NYCU

生醫感測Biomedical sensing

精準智慧醫療Precision Smart Healthcare

為兼顧微弱生理訊號的雜訊、線性度與耗能需求，研究團隊利用懸浮閘類比編程及互補式差動架構，發展可重組低雜訊放大器，並以閘極平衡虛擬電阻改善低頻失真。相關電路可調整增益與頻寬；不同設計及操作條件下，展示2.81 μVrms等效輸入雜訊，以及100 Hz頻寬下75 nW的低功耗感測。成果分別於2014年及2015年發表於IEEE Transactions on Biomedical Circuits and Systems與IEEE Transactions on Circuits and Systems II。To balance noise, linearity and energy needs for weak physiological signals, the team uses floating-gate analog programming and complementary differential architectures to develop reconfigurable low-noise amplifiers, with gate-balanced pseudo-resistors improving low-frequency distortion. Gain and bandwidth are adjustable. Different designs and operating conditions demonstrate 2.81μVrms equivalent input noise and 75 nW sensing power at 100 Hz bandwidth. Results appeared in IEEE Transactions on Biomedical Circuits and Systems in 2014 and IEEE Transactions on Circuits and Systems II in 2015.

在系統整合上，團隊將低雜訊放大器、濾波器、緩衝放大器及穩壓器整合為四通道類比感測前端，透過類比記憶體及串列介面設定增益、頻寬與訊號路徑。晶片於2020年底與臺大獸醫研究團隊合作進行癲癇動物腦波量測，並於ISCAS 2021發表；後續持續擴展多通道神經感測，相關八通道前端電路於APCCAS 2024發表。The team integrates low-noise amplifiers, filters, buffers and regulators into a four-channel analog sensing front end. Analog memory and serial interfaces configure gain, bandwidth and signal paths. In late 2020, collaboration with an NTU veterinary team measured EEG in epileptic animals; the result was presented at ISCAS 2021. Subsequent multichannel neural-sensing work included an eight-channel front end at APCCAS 2024.

在神經調控方面，研究團隊自2016年參與跨校醫工合作團隊，並於2017年至2019年計畫期間完成可選擇脈衝或指數衰減波形的四通道雙相位電流模式刺激晶片。設計以推挽式電荷補償控制刺激後殘餘電荷，並整合藍牙控制平台與手持裝置介面，完成大鼠及小鼠的癲癇抑制動物實驗。此成果提供可調整刺激參數並控制電荷平衡的電路與實驗平台；動物驗證結果構成後續研究的依據。Since 2016, the professor has participated in an inter-university medical–engineering collaboration. During the 2017–2019 project, the team completed a four-channel biphasic current-mode stimulator supporting pulsed and exponentially decaying waveforms. Push–pull charge compensation controls residual charge after stimulation. Bluetooth control and a handheld interface were integrated, and seizure-suppression animal experiments were conducted in rats and mice. These are circuit-platform and animal-validation results supporting further research.

原始研究說明：Research descriptions: 技術說明Technology description

相關公開論文Related public papers

依公開論文題名關鍵字篩選，共 11 篇，依公開年份與已載月份由新到舊排列；未載月份者置於該年最後。11 papers matched by title keywords, ordered by published year and stated month, newest first. Entries without a month follow dated entries in the same year.

  1. An Eight-Channel Analog Front-End Circuitry for the Application of Neural Signal Sensing

    in Proc. 2024 IEEE Asia Pacific Conference on Circuits and Systems (APCCAS), pp. 354-357, Taipei City, Taiwan, Nov. 7~9, 2024. (EI)

  2. A Current-Mode Electrical Stimulator with Charge Balance for Neural Stimulation Applications

    in Proc. 2024 IEEE Asia Pacific Conference on Circuits and Systems (APCCAS), pp. 772-775, Taipei City, Taiwan, Nov. 7~9, 2024. (EI)

  3. A biphasic current-mode stimulator integrated circuit with a novel residual charge compensation mechanism

    in Integration, vol. 91, pp. 79 - 88, July 2023.

  4. A Floating-Gate-Based Four-Channel Reconfigurable Analog Front-End Integrated Circuit

    in Proc. 2021 IEEE International Symposium on Circuits and Systems (ISCAS), pp. 1-4, Daegu, South Korea, May 22~28, 2021. (EI)

  5. Deep Brain Stimulation of Multi-Channel Shape-Selection Current-Mode Functional Electrical Stimulator

    2019 IEEE International Conference on Analog VLSI Circuits (AVIC 2019), Yilan, Taiwan, Oct. 28~30, 2019.

  6. A Power-Efficient Highly-Linear Reconfigurable Biopotential Sensing Amplifier Using Gate-Balanced Pseudo Resistors

    IEEE Transactions on Circuits and Systems II: Express Briefs, vol. 62, no. 2, pp. 199-203, Feb. 2015.

  7. A Fully Reconfigurable Low-Noise Biopotential Sensing Amplifier with 1.96 Noise Efficiency Factor

    IEEE Transactions on Biomedical Circuits and Systems, vol. 8, no. 3, pp. 411-422, June 2014.

  8. A Fully Reconfigurable Low-Noise Biopotential Sensing Amplifier

    in Proc. 2013 IEEE Biomedical Circuits and Systems Conference (BioCAS), Rotterdam, Netherlands, Oct. 31~Nov. 2, 2013, pp. 234-237. (EI)

  9. Front-end CMOS Electronics for Monolithic Integration with CMUT Arrays: Circuit Design and Initial Experimental Results

    in 2008 IEEE Ultrasonics Symposium, pp. 390-393, Beijing, China, Nov. 2008. (EI)

  10. Design Optimization and Integrated Electronics for Dual Electrode CMUTs

    in IEEE International Ultrasonics Symposium (IUS 2007), New York, NY, Oct. 2007. (EI)

  11. Floating-Gate Based CMUT Sensing Circuit Using Capacitive Feedback Charge Amplifier

    in Proc. 2006 IEEE Ultrasonics Symposium, 2006, pp. 2425–2428.

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